Early researchers noticed that GLP-1 powerfully and appropriately stimulated insulin only when glucose levels were high, meaning it lowered blood sugar without causing dangerous hypoglycemia, says New York internist and longevity expert Amanda Kahn, MD
Gerstein HC, Hart R, Colhoun HM, Diaz R, Lakshmanan M, Botros FT, Probstfield J, Riddle MC, Ryden L, Atisso CM, Dyal L, Hall S, Avezum A, Basile J, Conget I, Cushman WC, Hancu N, Hanefeld M, Jansky P, Keltai M, Lanas F, Leiter LA, Lopez-Jaramillo P, Munoz EGC, Pogosova N, Raubenheimer PJ, Shaw JE, Sheu WH, Temelkova-Kurktschiev T
To maximize absorption and efficacy, polyphenols should be consumed with healthy fats, such as those from olive oil or avocados, or in formulations that enhance bioavailability, such as curcumin with piperine
Some people may see substantial benefits even at lower doses
Taken together, these results demonstrated that cardioprotective effects against MG-induced mitochondrial dysfunction are mediated through both GLP-1R-dependent and -independent pathways
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