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Metabolism and Pharmacokinetics (Panel 2) : The drug operates with a rapid 3 to 5 minute half-life, which translates to a short clinical duration of approximately 6 to 10 minutes

He L., Tian Y., Liu Q., Bao J., and Ding R

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Abbreviations indicate half-life (T 1/2 ), maximum plasma concentration (C max ), time for maximal plasma concentration (T max ) and area under the curve from zero to last valid measurable concentration-timepoint (AUC 0-t )

Due to these results, Amgen expects to initiate a phase 3 development program (85)