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Several types of allelic variation have been identified within classes, with GSTM1 -null, GSTT1 -null and GSTP1-Ile105/Ile105 conferring impaired catalytic activity

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Furthermore, in all of these structures the C-terminal arm is aligned by the conserved guiding bar residue Asn419 hTrxR1 (Asn518 in TGR) through a strong hydrogen bond