One GSTZ1 encoded protein lacks the glutathione binding site and is, therefore, unlikely to exhibit the enzymatic activity of the other three isoforms
The conditions that have been associated with glutathione deficiency include the following: Neurodegenerative diseases such as Alzheimers, Parkinsons and Huntingtons disease and ALS Pulmonary diseases such as COPD, asthma, and acute respiratory distress syndrome Immune system disorders Cardiovascular diseases such as high blood pressure, elevated cholesterol, and heart attacks Chronic age-related disorders such as cataracts, macular degeneration, hearing impairment, and glaucoma Liver disease Cystic fibrosis Aging processes (Pizzorno, 2014)
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Pharmacokinetics and blood brain barrier penetration of (+)-catechin and ()-epicatechin in rats by microdialysis sampling coupled to high-performance liquid chromatography with chemiluminescence detection
