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Semaglutide has a molecular weight of approximately 4,114 daltons

Our data not only unveils a previously unknown pathway of ERMCS-localised GPCR signalling into mitochondria, potentially applicable to other GPCRs beyond the GLP-1R, but also opens the door to further roles of the GLP-1R in the regulation of mitochondrial lipid metabolism, a process tightly linked to changes in mitochondrial morphology governed by MICOS complex activity 10

A 2023 review in Cells described these agents as promising therapies across cardiovascular, renal, neurodegenerative, and metabolic conditions, while noting that the relative contribution of direct cellular effects versus improved cardiometabolic regulation remains under investigation [4]

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doi: 10.1186/s12906-018-2180-2