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The country's largest insurer is seeing a mixed response from clients in how they're responding to the growing clamor for GLP-1 therapies, executives said Friday

Reduced caloric intake due to appetite suppression may lead to insufficient energy consumption, particularly during the initial treatment phase

GLP-1 receptors are expressed in reward-related regions, such as the nucleus accumbens (NAc) and ventral tegmental area (VTA), where they influence dopaminergic signaling [43]

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