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Similarly, TRP levels, which were decreased in cancer patients receiving treatment with IL-2 and IFN-, significantly correlated with the emergence of depressive symptoms [96]

Earlier studies suggest that semaglutide (sold as Ozempic, Wegovy, and Rybelsus) may cause more digestive issues, including diarrhea, than older GLP-1 medications like liraglutide (Saxenda and Victoza)

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Particularly noteworthy is the discovery that melatonin signaling in -cells led to a decrease in the activation of the stress response c-Jun N-terminal kinase [136]

Free Radic Biol Med 41(7):10791091