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Unlike corticosteroids or broad immunosuppressants, KPV does not appear to suppress immune function globally its NF-kB inhibition is targeted and does not eliminate the immune response, only attenuates the pro-inflammatory cascade
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Referenced Citations Drmic D
The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference
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