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Several complex I inhibitors have been evaluated clinically and discontinued due to neurotoxicity and adverse side effects (IACS-010759, Tamoxifen, Piericidin A, Phenformin) ( A limitation of this study is the discrepancy between the strong in vitro synergy of the MitoQ + DPI combination and its limited effectiveness in in vivo models of NB

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however, serum leptin was significantly reduced in OLETF rats in the taurine group compared with the control group

Always calculate and stay well under the toxic dose for the patients weight