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Zhang et al., 2020c)

It accounts for more than 56,000 emergency room visits, 2,600 hospitalizations, and an estimated 500 deaths per year due to acute liver failure

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(iii) without diagnosed moderate-severe obstructive sleep apnea

FOXO4-DRI at 25 mM concentration selectively induced p53 nuclear exclusion and apoptosis in the senescent Leydig cells, confirmed by Annexin V-FITC/PI apoptosis assays and immunofluorescent staining of Ser15-phospho-p53 foci