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4 Nrf2 binds antioxidant response elements (AREs) and induces phase II detoxification enzymes, including glutathione S transferases (GSTs), nicotinamide adenine dinucleotide (phosphate) hydrogen [NAD(P)H] quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO-1), and enzymes for GSH synthesis

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These findings underscore the multifaceted involvement of various cell types in the complex pathogenesis of AA (Figure 2)

Reducing Oxidative Stress Every time your liver processes a toxinwhether it's from a glass of wine, a prescription medication, or environmental smogit produces free radicals