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A 2020 systematic review in Nutrients concluded that L-carnitine supplementation may have a 'slight ergogenic effect' in some contexts but that the overall evidence is 'weak and heterogeneous.' For weight loss, the data is even less compelling

Weve had drugs to reduce alcohol intake since the early 1950s

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Cancer Res 64 : 236242 Girnita L, Girnita A, Brodin B, Xie Y, Nilsson G, Dricu A, Lundeberg J, Wejde J, Bartolazzi A, Wiman KG, Larsson O (2000) Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact

The FDA does not evaluate supplement efficacy claims