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Research is ongoing, and more human studies are needed

Scientific References Cellular studies demonstrate increased lipolysis and fatty acid oxidation in differentiated adipocytes Animal models show reduced diet-induced obesity and improved insulin sensitivity with NNMT inhibition NAD+ metabolomics studies confirm restoration of cellular NAD+ and SAMe pools following NNMT blockade

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Its a circular problem, and its not entirely unfair to point that out

A separate 2019 study in older mice reported that NNMT inhibition was associated with how muscle stem cells supported regeneration in rodent models a different research angle from the metabolic work