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Additional categories being evaluated include apolipoprotein E \(\varepsilon\) 4 ( APOE4 ) effects, lipids and lipoprotein receptors, neurogenesis, oxidative stress, bioenergetics and metabolism, vascular factors, cell death, growth factors and hormones, circadian rhythm, and epigenetic regulators

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Misdiagnoses of Arthritis, Fibromyalgia and Chronic Fatigue Syndrome are common because many of the symptoms, especially joint and muscle pain, chronic fatigue, headaches, autonomic dysfunction, and other symptoms overlap with those of EDS

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