doi:10.7759/cureus.6103 Pohl D, Van Oudenhove L, Tornblom H, Le Neve B, Tack J, Simren M
With advancements in molecular diagnostics, a deeper understanding of HR+/HER2 breast cancer has been achieved, and several pathway inhibitors, as well as immunotherapies, are showing increasing promise
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While our in vitro developability assessments were performed on a small cohort of target-specific, high-expression antibodies from each repertoire and requires validation in a larger, more unbiased subset to definitively attribute native pairing to gains in developability, the bioinformatic workflows employedparticularly our clustering-based clonal selection strategiessuggest that the selected antibodies should be representative in sequence and function of the larger target-specific diversity