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Initially identified as a growth factor that stimulates the differentiation of bone marrow progenitor cells into granulocytes and macrophages, GM-CSF also activates various signaling pathways, including JAK/STAT, MAPK, and PI3K, through JAK2 activation, thereby influencing immune functions (6265)

The idea

Both are early enough in development that the published endpoints are surrogates body weight, HbA1c, liver fat measured over trial-length follow-up

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Protective effects of Clostridium butyricum in a murine model of dextran sodium sulfate-induced colitis that involve inhibition of the TLR2 signaling pathway and T helper 17 cells