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The reduction in ROS production, as a result of NRF2 activity, contributes to the destabilization of HIF1, furthering the anti-inflammatory activity of itaconate

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Lee YW, Hennig B, Fiala M, Kim KS, Toborek M: Cocaine activates redox-regulated transcription factors and induces TNF-alpha expression in human brain endothelial cells

However, cranial magnetic resonance imaging showed a wide range of long T1 and T2 signals in the bilateral frontotemporal parietal lobes, short T1 signals in the bilateral pallidum (Figure 2)