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In the pro-estrous (high estradiol) phase of the estrous cycle, estradiol increases leptin mRNA expression and serum leptin levels (153)

As shown in Supplementary Table 1, MMA was positively correlated with Creatinine, Blood urea nitrogen, and C-Peptide (r = 0.388, 0.293, and 0.229, respectively), while inversely correlated with High-density lipoprotein-cholesterol (HDL-C), eGFR, and B12 (r = -0.102, -0.405, and 0.291, respectively)