Taking both together makes sense for most people, though folate status should be adequate before starting high-dose b12 to avoid masking folate deficiency
The approach is also compatible with the controlled production in stirred tank bioreactors as recently demonstrated for cardiac and hematopoietic lineages 77,78 and will provide the field with a potentially game-changing resource to allow the development of clinical as well as screening platforms where the requirement will be in the millions of organoids rather than todays laboratory scale
It is not appropriate for personal wellness, anti-aging experiments, or unsupervised use
Writing and critical review of the manuscript: RG, KL, ABC, VYS, JLH
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