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Five biological mechanisms account for the vast majority of lip discoloration cases: cumulative UV exposure, tobacco-induced melanocyte activation, post-inflammatory hyperpigmentation following irritation or injury, hormonal melasma-type pigmentation, and allergic reactions to cosmetic products

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Embora esses estudos sejam publicados em revistas indexadas, a replicao independente por outros grupos de pesquisa permanece insuficiente para tirar concluses definitivas sobre a eficcia teraputica em humanos