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But our natural GLP-1 satiety mechanism fails, because most food components are rapidly digested and absorbed at the beginning of our small intestine, and dont make it way down to the end of the small intestine where our GLP-1-secreting cells are concentrated

Together they produce amplified, pulsatile GH secretion while preserving physiological feedback

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This article has a large sample size (227 participants) and a long follow-up period (12 months), which may be the reason why the control group has more adverse events than other clinical trials

doi: 10.1104/pp.103.030940