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In LPS and CLP-induced AKI models, renal tubular cells can protect renal function by inducing PINK1/Parkin-mediated mitochondrial autophagy, suggesting that the PINK1/Parkin pathway may be an effective therapeutic target for AKI[113]

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Thus, gene therapy with viral vectors protects from neuronal death in animal models of ALS (Lee et al., 2019) and cerebral ischemia (Hayashi et al., 2001), promotes angiogenesis, and reduces apoptosis in SCI (Kitamura et al., 2007)