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Retrieved 10 February 2026

However, not all glucose-lowering and risk-factor management trials have shown a positive effect on CV events over the relatively short timeframe of CVOTs and therefore, risk-factor modification alone cannot explain the magnitude of the benefits observed ( Figure 3 ) ( Figure 3 In atherogenesis, low-density lipoprotein (LDL) cholesterol is transported into the intima layer of arterial blood vessels where reactive oxygen species (ROS) can lead to the formation of oxidized LDL (oxLDL) particles

Semaglutide, marketed as Ozempic and Wegovy, has been called a breakthrough in weight management

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This dual mechanism enhances insulin secretion, suppresses glucagon release, slows gastric emptying, and reduces appetite