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In the SYNERGY-NASH trial, tirzepatide showed significant rates of MASH resolution, up to 62%, compared to 10% with placebo, and improved fibrosis in over 50% of participants, said Isaacs

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Metagenomics and faecal metabolomics integrative analysis towards the impaired glucose regulation and type 2 diabetes in Uyghur-Related omics

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As the loss of POLRMT results in severe mitochondrial dysfunction in cardiac muscle 70 , a similar mitochondrial dysfunction should occur in beta-cells with the loss or dysfunction of POLRMT, resulting in insulin resistance and diabetes mellitus