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Newer GLP-1 RAs like semaglutide are copied after the human GLP-1 form

The reduction in MACE observed in treatment with GLP-1RAs is mainly driven by a significant reduction in fatal or non-fatal stroke, but also a significant reduction in risks for CV death and fatal or non-fatal myocardial infarction (15), suggesting that GLP-1RAs may exert their cardioprotective effects through anti-atherosclerotic mechanisms

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Studies show that when GLP-1 therapy is discontinued without concurrent metabolic and lifestyle integration weight regain is common

[DOI] [PMC free article] [PubMed] 19.Simon J.A., Kingsberg S.A., Goldstein I., Kim N.N., Hakim B., Millheiser L