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The 500 Dalton rule (molecular weight below 500 Da correlates with percutaneous absorption) is a necessary but not sufficient condition, not a guarantee

Yan J, Pan Y, Xiao J, Ma W, Li L, Zhong M, et al

Reproductive performance was also assessed in a one-generation study on rats at dietary levels of 0, 200, 375, 750, 1500 or 3000 mg/kg diet with groups of 15 males and 15 females

Dihexa demonstrates synaptogenic activity approximately seven orders of magnitude more potent than brain-derived neurotrophic factor (BDNF) in preclinical models