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PMID 34457340

While the latter might be relevant to conditions such as pathogen challenge, current concepts suggest that the relatively low antioxidant complement of the apoplast enables this compartment to exist in a more oxidized state compared to the cell interior (Pignocchi et al

What this means for clinical research: Clinical development in 2026 is increasingly geographically modular, requiring sponsors and CROs to coordinate multi-region strategies earlier and manage data, quality, and regulatory alignment across jurisdictions

Raffaghello, L

It is also unclear whether patients would have to take these drugs for the rest of their lives or in combination with other procedures and therapies