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Potential adverse effects relevant to reproductive health Reported, as well as theoretically plausible, side effects include immune reactions, changed gut motility, and tissue growth

J Clin Invest 113(1):1418

At the primary end point of 16 weeks, an ACR20, 50 and 70 response was achieved by 86%, 73% and 49% of the combination therapy patients, compared with 67%, 40% and 19% of those receiving methotrexate alone (Figure 7-10)

Rotate the site every time, because injecting the same spot repeatedly can cause a fatty lump (lipohypertrophy) that slows absorption, a point the NHS is clear about when it advises you to rotate sites daily