how to get out of a glp 1 stall Jennifer Manne-Goehler, MD, ScD, explains why GLP-1 medications shouldn't be used as "quick fix" and outlines what consider before taking them Most stalls aren’t the GLP-1

Glucagon receptor activation increases metabolic rate by stimulating thermogenesis in brown adipose tissue and enhancing mitochondrial activity in hepatocytes and skeletal muscle

weeks 1-16 on tirzepatide Semaglutide GI rate / 44.2% nausea, 31.5% diarrhea, 23.4% constipation in STEP-1 (N=1,961) Tirzepatide GI rate / approximately 80% of patients on 15 mg reported at least one GI effect in SURMOUNT-1 (N=2,539) First-line fix / avoid high-sulfur foods (eggs, garlic, cruciferous vegetables) on injection days Medication option / simethicone (Gas-X, 125 mg) or bismuth subsalicylate (Pepto-Bismol) may reduce odor and frequency Serious warning / new right-upper-quadrant pain plus burping may signal gallbladder disease, not routine GI upset Discontinuation / roughly 7% of semaglutide 2.4 mg patients stopped due to GI side effects in STEP-1 Dose strategy / slower titration reduces GI burden without meaningfully reducing weight loss outcomes What Causes Sulfur Burps on GLP-1 Drugs GLP-1 receptor agonists slow gastric emptying as a deliberate pharmacological effect

Semaglutide also slows the stomach emptying, leading to a feeling of fullness and reduced hunger

Your move: Seek medical attention right away

Werkman et al