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Molecular and biochemical mechanisms mainly included the increased oxidative stress through polyol pathway flux, the accumulation of advanced glycation end products, the hexosamine pathway, and the protein kinase C pathway

Indian Journal of Clinical Anaesthesia

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Also, as you age, enzymes start decreasing in your body

However, the FDA has signaled increasing scrutiny of whether these modifications truly constitute clinical differentiation or are simply cosmetic changes designed to circumvent the ban on copying commercially available drugs