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Hypoxia then stabilizes HIF-1 and upregulates REST, which suppresses GCLM/GPX4 expression and enhances ACSL4-dependent lipid peroxidationdirectly amplifying ferroptosiswhile also promoting the release of hypoxic extracellular vesicles (EVs) that propagate tubular ferroptosis in a paracrine manner

Hub targets expression analysis of BRCA in the TCGA database To further investigate the clinical value of the hub targets, BRCA data from the TCGA database were used for validation

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The pathological classification of melanocytic naevi relates to where naevus cells are found in the skin

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