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Effective natural antioxidants could provide novel and safe interventional strategies to delay or prevent ovarian aging and related diseases

Preclinical investigations have explored BPC-157 in relation to: Tendon and ligament recovery models Muscle tissue regeneration Gastrointestinal mucosal protection Inflammatory pathway modulation Vascular development and angiogenesis Much of the available data stems from animal studies, and human clinical data remains limited

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Mechanistically, the peptide has been studied as a pro-angiogenic agent that appears to work through the VEGFR2 receptor and the endothelial nitric-oxide synthase (eNOS)nitric-oxide pathway, and as a stimulator of fibroblast outgrowth and migration through the FAKpaxillin signaling pathway

J Thorac Cardiovasc Surg 168(1):263-271, 2024