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People were tested on these weekly doses: 1 milligram (mg) 4 mg (starting at either 2 mg or 4 mg) 8 mg (starting at either 2 mg or 4 mg) 12 mg (starting at 2 mg) The highest dose tested was 12 mg per week , and the gradual increase was important for making side effects easier to handle

With respect to dosage, the average reductions were: 2000 mcg: 71.5% (single data point) 1,000 mcg: 31.8% Although limited data are available for higher dosages, the findings support the efficacy of both oral and non-oral B12 formulations in modulating homocysteine levels

The exact number depends on the size of the area, the amount of fat present, and your individual response to the treatment