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These are all valid concerns

Diet-induced obese mice received vehicle or 5A1MQ for 28 days

The commonly used dietary methionine restriction regimen has been shown to extend life span, delay aging, prevent metabolic diseases, reduce cancer growth, and sensitize cancer cells to chemotherapy and radiation in mice 14,42,43

Combined with the molecular weight argument (semaglutide is too large to easily cross biological barriers into milk) and the poor oral bioavailability (any swallowed semaglutide would be destroyed in the infant gut), the safety profile looks reassuring