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Competing interests The authors declare that they have no competing interests

Importantly, this study also demonstrated that the B12 reduction associated with metformin use is not transitory but persists and progresses over time and, in some patients, to levels at which replacement is recommended

If you are a recreational athlete or non-competing fitness enthusiast, this prohibition does not apply to you directly, but it is worth knowing when evaluating claims made by coaches, trainers, or online vendors

More clinical research should investigate the effectiveness across different patient conditions, but the existing evidence suggests the treatments are generally safe, well tolerated, and worth trying for those struggling with chronic pain or steroid side effects

NDC: 70069-0171-10