A report published in January 2025 by the US Office of Inspector General identified significant flaws in accelerated approval processes for three drugs (Biogens Aduhelm/aducanumab, Sareptas Exondys/eteplirsen, and Covis Pharma Groups Makena/hydroxyprogesterone caproate), raising questions over the effectiveness and consistency of the fast track pathway
PMOS is a combination of hormonal and metabolic imbalances, in addition to insulin resistance, says functional medicine specialist Layth Tumah, MD
Electrolyte imbalances, which can cause irregular heart rhythms, weakness, muscle cramps, and loss of consciousness can and do happen to individuals who are losing weight without proper support and monitoring
Antioxidants (Basel) 9(10):989
As weight loss with any existing pharmaceutical intervention inevitably plateaus due to putative counterregulatory mechanisms, we further hypothesized that the postulated enhanced body weight suppressive effects of combined amylin- and GLP-1R-based pharmacotherapies could be even further enhanced if the drugs were introduced in a stepwise fashion, allowing the physiological systems to adjust to and overcome the tachyphylaxis that occurs with repeated drug treatments 21,22,23
