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135 Not all trials have yielded positive findings

Although the role of CD44 in the transport activity of xCT has not been validated so far, an interesting implication in iron endocytosis via CD44-bound hyaluronates is proposed (Figure 1)

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Systematic comparative data is limited, but the hypothesis is supported by general peptide chemistry principles around salt form and stability

Interventions targeting lipid peroxidation preserve NE integrity, extend lifespan in worms and ameliorate senescence-associated phenotypes in human fibroblasts and monkey cells mimicking HutchinsonGilford progeria syndrome disease