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2 A single oral dose of ivermectin may be ineffective in some scabies patients due to its lack of ovocidal action, requiring a second dose to kill newly hatched mites

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Paoletti J

REDEFINE (obesity) and REIMAGINE (T2D) are the main Phase 3 programs, with REDEFINE 1, 2, and 4 already reported

Thus, in order to achieve the desirable therapeutic effect and adequate safety of the drugs delivered to the brain via transporter-mediated approach, the focus should be on the thorough investigation of utilization of transporter for cellular uptake and detailed evaluation of the efficacy of drug delivery into the brain and within the brain