Is GLP-1 a Lifelong Solution
Upon initiation of a GLP-1 RAs and during up-titration, it is advisable for cardiologists to counsel their patients to take smaller meals, eat slowly and stop before feeling full, and avoid fatty or spicy foods (2)
Semaglutide does not trigger any of these antibodies because its molecular structure is entirely unlike anything on the panel
Further, although incompletely described, multiple studies are available to provide insights into the mechanistic underpinnings, which appear to be associated mostly with indirect cardioprotective benefits owing to the ability of GLP-1 RAs to address hyperglycaemia, and reduce body weight, and, amongst others, inflammation
Increased Risk of Thyroid and Other Cancers The FDA now requires a black box warning about this potential risk on these medications