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Disclaimer: These statements are not evaluated by the FDA

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Methionine is then converted into S-adenosylmethionine (SAM), which donates methyl groups in reactions catalyzed by methyltransferases, including DNA methylation, producing S-adenosylhomocysteine (SAH) that is converted back into homocysteine

This could trigger a positive feedback cycle whereby protein aggregates trigger the aggregation of other proteins in a chain reaction that eventually captures elements of the proteostatic mechanisms in place to counteract them