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It was demonstrated that inhibition of NF-B activation significantly inhibits LPS-induced GSDMD palmitoylation, and ROS scavengers in turn, inhibit NF-B activation

108 When endoplasmic reticulum stress (ERS) is severe and persistent, it can trigger apoptosis by activating the endoplasmic reticulum (ER) pro-apoptotic cysteine protease caspase-12 and inhibiting the expression of Bcl-2

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Yamabe, Y., Hoshino, A., Imura, N., Suzuki, T

Regarding iron metabolism, the iron chelator deferoxamine mesylate can treat experimental uveitis in Lewis rats, resulting in a significant reduction in choroidal inflammation and retinal damage [319]