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Describe the role of NADPH in detoxifying reactive oxygen species, and explain which cell types depend the most on the pentose phosphate pathway

Its hallmark pathological features including cartilage degradation, subchondral bone sclerosis, osteophyte formation and synovial inflammation, are fueled by a complex interplay of inflammatory cascades, oxidative stress, and mechanical stress imbalance (57)

E., & Draelos, Z

That popularity has led to a lot of exploration into the different mechanisms of delivery for the peptide, to find the right balance of primary effect and adverse side effects

Biomedicines 12 (3), 620