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This contraindication stems from observations in rodent studies where semaglutide and other GLP-1 receptor agonists caused dose-dependent and treatment-duration-dependent thyroid C-cell tumors

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This helps preserve lean muscle mass, promoting a healthier body composition, which is vital for long-term fitness and overall wellness

The central mechanism also means semaglutide simultaneously improves glycemic control, reduces cardiovascular risk factors, and addresses the metabolic consequences of obesity not just the fat stores themselves