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Finally, the increasing off-label use of GLP-1 RAs for weight loss in non-diabetic individuals may further exacerbate access limitations and drug shortages, potentially disadvantaging patients with T2DM

The Lipitor experience established a template that dozens of brand companies have since followed: maximize the PTE, negotiate carefully with first-filer generics to control the timing and price of their entry, and launch an authorized generic to maintain revenue participation even after exclusivity ends

With only 2 mg total, you need to be careful about dilution

Weight loss with semaglutide and liraglutide were significantly greater vs placebo (difference, 13.9 percentage points [95% CI, 16.7 to 11.0] and 4.5 percentage points [95% CI, 7.3 to 1.7])