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note in Nature Medicine , NNMT inhibition has been shown to enhance energy expenditure and promote fat loss, even without dietary modification (Kraus et al., Nature Medicine )
It was also reported that C57BL/6 mice pre-treated with cardamomin could rescue them from LPS-activated mortality in conjunction with the decreased TNF- serum level
In the context of glutamine depletion or inhibition of glutamine transport, in conjunction with ICD-inducing chemotherapeutic agents, a synergistic activation of IFN- occurs, leading to CD8 T-cell recruitment and an inhibition of cancer cell growth via the OTUD4/LDHA axis [97]
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