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Description

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Although canonically GLP1Rs signal through the stimulatory alpha Gs protein, we find that semaglutide utilizes both Gs- and Gq-signaling pathways in GLP1Rs in the area postrema (AP)the primary site of semaglutide action in the brainto differentially regulate neuronal activation across distinct neuronal clusters

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The Pernicious Anaemia Society and the NIH B12 professional fact sheet are both reliable places to read further

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