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In a large study published in the New England Journal of Medicine, Semaglutide (which is the active ingredient in both Ozempic) led to an average weight loss of about 15% of the body weight in about a year, which is an average total weight loss of about 33.7 lbs

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Other mechanisms presumably involve active tubular secretion via renal transporters (Organic Anion Transporter-3 (OAT3) or P-glycoprotein (P-gp))

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