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Given their increasing use, understanding their broader metabolic effectsincluding potential impacts on bone healthhas become an important area of clinical and research interest

Hepatocytes also showed specific downregulation of transcriptional and translational machinery, proliferation, and necroptosis ( Figure 6E )

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The company has multiple phase 3 clinical trials running to see how well retatrutide treats health conditions that often overlap with obesity, including knee osteoarthritis, moderate to severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes, and liver disease