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The cross-talk between tumor cells and activated fibroblasts mediated by lactate/BDNF/TrkB signaling promotes acquired resistance to anlotinib in human gastric cancer

Study design & population Using an active-comparator new-user cohort design [31, 32], we emulated three hypothetical active-controlled randomized trials comparing SGLT2 inhibitors, injectable GLP1 receptor agonists, and DPP4 inhibitors pairwise

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The ability of IL-1 to induce chondrocyte catabolism [121] has been well known for a long time, but it is only recently that IL-1 has been shown to disrupt chondrocyte iron homeostasis [117] and trigger chondrocyte ferroptosis [22, 122]

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