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Furthermore, recent data indicates effectiveness in inhibiting fibrosis advancement, with clinical studies revealing markedly reduced progression rates in individuals treated with semaglutide (5%) compared to placebo groups (19%) (Newsome et al

Current evidence is derived primarily from preclinical studies and a limited number of clinical trials, which may not fully represent the diverse HFpEF population

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527 Conclusions and perspective Primarily recognized for their role in diabetes mellitus treatment, GLP-1RAs have demonstrated significant benefits in cardiovascular health, skeletal muscle-related diseases, obesity management, and neurodegenerative conditions, among others

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